For patients with recurrent pregnancy loss

Emotional support

  1. 1European Society of Human Reproduction and Embryology (ESHRE) Early Pregnancy Guideline Development Group. Recurrent Pregnancy Loss Guideline. 2017. 11.
  2. 2Sugiura-Ogasawara M, Ebara T, Matsuki T, Yamada Y, Omori T, Matsumoto Y, Kato S, Kano H, Kurihara T, Saitoh S, Kamijima M; and the Japan Environment & Children's Study (JECS) Group. Endometriosis and recurrent pregnancy loss as new risk factors for venous thromboembolism during pregnancy and post-partum: The JECS Birth Cohort. Thromb Haemost. 2019; 119: 606-617.
  3. 3Sugiura-Ogasawara M, Suzuki S, Ozaki Y, Katano K, Suzumori N, Kitaori T. Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: The Okazaki Cohort Study in Japan. J Obstet Gynaecol Res. 2013; 39: 126-31.
  4. 4Sugiura-Ogasawara M, Ozaki Y, Kitaori T, Kumagai K, Suzuki S. Midline uterine defect size correlated with miscarriage of euploid embryos in recurrent cases. Fertil Steril 93: 1983-1988, 2010
  5. 5Sugiura-Ogasawara M, Ozaki Y, Katano K, Suzumori N, Kitaori T, Mizutani E. Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage. Hum Reprod 2012; 27: 2297-2303.
  6. 6Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement of an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306.
  7. 7Katano K, Aoki K, Sasa H, Ogasawara M, Matsuura E, Yagami Y. beta 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod. 1996;11: 509-512.
  8. 8Sugiura-Ogasawara M, Atsumi T, Yamada H, Kitaori H, Ozaki Y, Katano K, Murashima A. Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies. Modern Rheumatology 2015; 30: 1-22.
  9. 9Ogasawara MS, Aoki K, Katano K, Ozaki Y, Suzumori K. Factor XII but not protein C, protein S, antithrombin III or factor XIII as a predictor of recurrent miscarriage. Fertil Steril 2001; 75: 916-919.
  10. 10Sugiura-Ogasawara M, Omae Y, Kawashima M, Toyo-oka L, Khor SS, Sawai H, Horita T, Atsumi T, Murashima A, Fujita D, Fujita T, Morimoto S, Morishita E, Katsuragi S, Kitaori T, Katano K, Ozaki Y, Tokunaga K. The first genome-wide association study identifying new susceptibility loci for obstetric antiphospholipid syndrome. J Hum Genet. 2017; 62: 831-838.
  11. 11Ogasawara M, Aoki K, Kajiura S, Yagami Y. Are antinuclear antibodies predictive of recurrent miscarriage? Lancet 1996;347: 1183-1184.
  12. 12Cowchock FS, Reece EA, Balaban D, Branch DW, Plouffe L. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 1992; 166: 1318-1323.
  13. 13Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314: 253-257.
  14. 14Sugiura-Ogasawara M, Ozaki Y, Nakanishi T, Sato T, Suzumori N, Nozawa K. Occasional antiphospholipid antibody positive patients with recurrent pregnancy loss also merit aspirin therapy: A retrospective cohort-control study. Am J Reprod Immunol 2008; 59: 235-241.
  15. 15Yoshihara H, Sugiura-Ogasawara M, Kitaori T, Katano K, Ozaki Y.  Danaparoid is effective and safe for patients with obstetric antiphospholipid syndrome. Mod Rheumatol. 2019 Mar 29:1-6.
  16. 16Sugiura-Ogasawara M, Ozaki Y, Sato T, Suzumori N, Suzumori K. Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 2004; 81: 367-373.
  17. 17Franssern MTM, Korevaar JC, van der Veen F,et al. Reproductive outcome after chromosome analysis in couples with two or more miscarriages: case-control study. BMJ 2006; 332, 759-762.
  18. 18Sugiura-Ogasawara M, Aoki K, Fujii T, Fujita T, Kawaguchi R, Maruyama T, Ozawa N, Sugi T, Takeshita T, Shigeru Saito. Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. J Hum Genet 2008; 53, 622-628.
  19. 19Ikuma S, Sato T, Sugiura-Ogasawara M, Nagayoshi M, Tanaka A, Takeda S. Preimplantation genetic diagnosis and natural conception: A comparison of live birth rates in patients with recurrent pregnancy loss associated with translocation. PlosOne. 2015 Jun 17;10(6):e0129958.
  20. 20Rikken JFW, Verhorstert KWJ, Emanuel MH, Bongers MY, Spinder T, Kuchenbecker W, Jansen FW, van der Steeg JW, Janssen CAH, Kapiteijn K, Schols WA, Torrenga B, Torrance HL, Verhoeve HR, Huirne JAF, Hoek A, Nieboer TE, van Rooij IAJ, Clark TJ, Robinson L, Stephenson MD, Mol BWJ, van der Veen F, van Wely M, Goddijn M.  Septum resection in women with a septate uterus: a cohort study.Hum Reprod. 2020 Apr 30:dez284.
  21. 21Rodger MA, Hague WM, Kingdom J, Kahn SR, Karovitch A, Sermer M, Clement AM, Coat S, Chan WS, Said J, Rey E, Robinson S, Khurana R, Demers C, Kovacs MJ, Solymoss S, Hinshaw K, Dwyer J, Smith G, McDonald S, Newstead-Angel J, McLeod A, Khandelwal M, Silver RM, Le Gal G, Greer IA, Keely E, Rosene-Montella K, Walker M, Wells PS, TIPPS Investigators. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 2014; 384(9955): 1673-1683.
  22. 22Ogasawara M, Katano K, Aoyama T, Kajiura S, Aoki K. Are serum progesterone levels predictive of recurrent miscarriage in future pregnancies? Fertil Steril 1997; 68: 806-809.
  23. 23Coomarasamy A, Williams H, Truchanowicz E, Seed PT, Small R, Quenby S, Gupta P, Dawood F, Koot YE, Bender Atik R, Bloemenkamp KW, Brady R, Briley AL, Cavallaro R, Cheong YC, Chu JJ, Eapen A, Ewies A, Hoek A, Kaaijk EM, Koks CA, Li TC, MacLean M, Mol BW, Moore J, Ross JA, Sharpe L, Stewart J, Vaithilingam N, Farquharson RG, Kilby MD, Khalaf Y, Goddijn M, Regan L, Rai R. A randomized trial of progesterone in women with recurrent miscarriages. N Engl J Med. 2015; 373(22): 2141-8.
  24. 24Coomarasamy A, Devall AJ, Cheed V, Harb H, Middleton LJ, Gallos ID, Williams H, Eapen AK, Roberts T, Ogwulu CC, Goranitis I, Daniels JP, Ahmed A, Bender-Atik R, Bhatia K, Bottomley C, Brewin J, Choudhary M, Crosfill F, Deb S, Duncan WC, Ewer A, Hinshaw K, Holland T, Izzat F, Johns J, Kriedt K, Lumsden MA, Manda P, Norman JE, Nunes N, Overton CE, Quenby S, Rao S, Ross J, Shahid A, Underwood M, Vaithilingam N, Watkins L, Wykes C, Horne A, Jurkovic D. A randomized trial of progesterone in women with bleeding in early pregnancy. N Engl J Med. 2019; 380(19): 1815-1824. d
  25. 25van den Boogaard E, Vissenberg R, Land JA, van Wely M, van der Post JA, Goddijn M et al. Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Hum Reprod Update 2011;17:605-19.
  26. 26Dhillon-Smith RK, Middleton LJ, Sunner KK, Cheed V, Baker K, Farrell-Carver S et al. Levothyroxine in women with thyroid peroxidase antibodies before conception. N Engl J Med 2019;380:1316-25.
  27. 27Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000; 73: 300-304.
  28. 28Gayathree Murugappan, Lora K. Shahine, Candice O. Perfetto1, Lee R. Hickok, and Ruth B. Lathi. Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss. Hum Reprod 2016; 31: 1668–1674
  29. 29Sato T, Sugiura-Ogasawara M, Ozawa F, Yamamoto T, Kato T, Kurahashi H, Kuroda T, Aoyama N, Kato K, Kobayashi R, Fukuda A, Utsunomiya T, Kuwahara A, Saito H, Takeshita T, Irahara M: Japan Society of Obstetrics and Gynecology. Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure. Hum Reprod 2019 Dec 1;34(12):2340-2348.
  30. 30Kaandorp SP, Goddijn M, van der Post JAM, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010; 362, 1586-96.
  31. 31Hayashi Y, Sasaki H, Suzuki S, Nishiyama T, Kitaori T, Mizutani E , Suzumori N, Sugiura-Ogasawara M. Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss. Fertil Steril 2013; 100: 1018-1024.
  32. 32Banno C, Sugiura-Ogasawara M, Ebara T, Ide S, Kitaori T, Sato T, Ando K, Morita Y. Attitude and perceptions toward miscarriage: a survey of a general population in Japan. J Hum Genet. 2020 Jan;65(2):155-164.