For patients with recurrent pregnancy loss
Drug administration for repeated miscarriages of unknown cause
We have tried various treatments for unexplained RPL in the past, including immunotherapy, aspirin, heparin, Picibanil (OK-432) and steroids. However, we have seen no increase in the live birth rate compared to using no drug therapy at all.
In our study, 85% of couples with no marital chromosomal abnormalities or uterine malformations ultimately gave birth.
The rate of having a live birth with the next pregnancy
ogit(ps)=3.964-0.0652×(woman's age) - 0.408×(number of previous miscarriages)
You can estimate your chance of a live birth using the formula. Enter your age and the number of miscarriages you have had (but the calculation will not be accurate if you have more than seven). This will give you an idea of the success rate of delivery in your next pregnancy.
The use of Picibanil was equivalent to immunotherapy with the husband’s lymphocytes. In other words, it is equivalent to saline and is not that effective.
The same is true for heparin. The results of a randomized trial of aspirin-heparin therapy, aspirin alone, or a sham agent for unexplained RPL clearly had no effect (30). There are a number of centers that offer aspirin-heparin therapy for unexplained conditions in accordance with APS treatment.
- Definition of recurrent miscarriage and recurrent pregnancy loss and results of the Japan Environment and Children’s Study (JECS)
- Examination and causes of RPL
- Antiphospholipid syndrome
- Treatment of antiphospholipid syndrome
- Chromosomal translocation in either partner
- Preimplantation genetic testing for chromosomal structural rearrangement
- Congenital uterine anomaly
- Thrombotic predisposition
- Endocrine abnormality
- Fetal or embryonic aneuploidy
- Preimplantation genetic testing for aneuploidy
- Immunotherapy for unexplained recurrent miscarriage
- Drug administration for repeated miscarriages of unknown cause
- Unknown Causes
- Emotional support